Description
Product Characteristics:
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Subcellular location: Nucleus
Synonyms: Homeo box 11 (T cell leukemia 3 associated breakpoint homologous to Drosophila Notch), Homeo box 11 (T cell lymphoma 3 associated breakpoint), Homeobox 11, Homeobox protein Hox 11, Homeobox protein Hox-11, Homeobox TLX-1, Hox-11, Hox11, MGC163402, OTTHUMP00000020816, Proto oncogene TCL 3, Proto-oncogene TCL-3, RGD1563655, T cell leukemia homeobox protein 1, T cell leukemia lymphoma protein 3, T-all, included, T-cell acute lymphocytic leukemia, included, T-cell leukemia 3 gene, T-cell leukemia homeobox protein 1, T-cell leukemia, homeobox 1, T-cell leukemia/lymphoma protein 3, TCL 3 proto oncogene, TCL3, Tlx-1, TLX1, TLX1_HUMAN.
Target Information: This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]